Getting My ceesdekker.net To Work

Nanotechnology features a range of possibilities to contribute to biology. Right here I will current examples the place nanofabrication – the opportunity to make confined buildings with Proportions at will – is made use of to examine the biophysics of single molecules and cells. I will present some illustrations from our lab:

Our team scientific tests bacterial mobile division and it is aiming to constitute a ‘base up biology’ in synthetic cells that may autonomously divide. Our main desire lies in cell division, chromatin structure, and spatial Command.

, Groningen scientists existing the effects in their endeavours to make labs more sustainable and provide strategies for other labs. 

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and very first at any time examine of the dynamics DNA supercoils and the invention of supercoil hopping

Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes

All parameters were being exactly the same for each panel In this particular movie, apart from the First placement of your 6hb rod (shown in blue) around the nanopore. Simulations that terminated early on account of translocation of your rod in the pore are marked by a gray history.

Studying DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.

2003, shown the primary biosensors manufactured from a carbon nanotube; resolved the structure and system of DNA mend proteins; and discovery of a whole new approach for fabricating strong-state nanopores for DNA translocation

Dekker commenced his analysis on single carbon nanotubes in 1993 when he build a whole new line of analysis to check electrical transportation via one natural molecules between nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was attained in a collaboration Along with the group of Nobel laureate Richard Smalley. STM and nanolithography procedures have been used to reveal that these nanotubes are quantum wires at The only-molecule amount, with exceptional Actual physical Homes.

Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with research from scientific tests of DNA loop extrusion and supercoiling to DNA translocation by means of nanopores. More not long ago his analysis has centered cees dekker on learning chromatin composition and cell division with microbes on chip, although he is also trying to ultimately Create artificial cells from the bottom up.

Nature Physics many thanks the anonymous reviewers for his or her contribution on the peer assessment of the operate.

Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes

 Finally, I will briefly sketch some of our Tips to investigate the constructing of synthetic cells, particularly our very first methods to ascertain synthetic cell division.